Objective: To evaluate the effectiveness and safety of Intratympanic methylprednisolone injection in patients with sudden sensorineural hearing loss (SSNHL) by means of a comparison between subjective and objective outcomes and a review of the literature regarding methylprednisolone transtympanic administration. Data Sources: An electronic database search (MEDLINE and PubMed) was performed with the objective of identifying all studies published in the English language between January 1980 and October 2014 on the treatment of intratympanic methylprednisolone injection in ISSNHL. Prospective, non-randomized, case review of patients diagnosed with ISSNHL treated with intratympanic methylprednisolone from January 1, 2012 to June 1, 2014. Study Selection: Twenty-seven articles describing intratympanic methylprednisolone injection in ISSNHL Data Extraction: Mean, standard deviation and extreme values were presented in continuous variables; absolute value and proportions for categorical variables. The results were expressed as mean ± standard deviation (SD). The comparison between categorical variables was evaluated by the χ 2 test or the continuity correction χ 2. Data Synthesis: The entire analysis was performed using the SPSS package, version 15.0 (SPSS package Inc.) Conclusion: Intratympanic methylprednisolone injection is a valid and safety option as a rescue therapy and also as first line treatment according to objective and subjective outcomes. It is the first time in which a correlation between subjective and objective outcomes could be established.