No abstract

Combinatorial chemistry with a newly‐developed screening procedure using complementary fluorescein‐ and rhodamine‐labelled oligonucleotides (below) has been used to select peptide dsDNA binding ligands. A high structure–affinity relationship of the dsDNA‐binding unnatural peptide was observed.

Sprays with high density of unsolvated biomolecule ions that are produced within an electrospray ionization (ESI) plume under ambient conditions are discussed by R. Zenobi and co‐workers in their Communication on The method substantially enhances the experimental arsenal for probing the intrinsic properties biomolecules.