These results suggest that PEN110 inactivates HIV-1 by targeting the viral nucleic acid.

This study describes model systems to the relevant forms of CMV in blood and detection assays that can be used to evaluate the efficacy of viral inactivation agents.

These results demonstrate that gamma irradiation, at levels currently used to treat RCC, has the capacity to induce expression of CMV, whereas PEN110 inhibits CMV replication and efficiently inactivates the infected cells.