This study examined the relationship between certain predictor variables and the degree of burnout experienced by teachers of students with moderate to profound mental retardation. The Maslach Burnout Inventory (MBI Form Ed) was used to measure the perceived burnout of 68 respondents. Demographic data and ratings of perceived burnout of 68 respondents. Demographic data and ratings of perceived organizational factors were also obtained from each participant. A maximum R2 regression analysis revealed significant predictor variables for each of the MBI Form Ed subscales. The age of the students and the teachers' perceived level of supervisory support were found to be significantly related to Emotional Exhaustion scores. For the Depersonalization dimension, the respondents' educational status and their perception of collegial support were found to be significantly related.