We report a case of fulminant supraglottitis with dramatic external cervical swelling due to associated cellulitis. Blood cultures were positive for Neisseria meningitidis. The patient recovered completely after emergency fiberoptic intubation and appropriate antibiotic therapy. We summarize five other cases of meningococcal supraglottitis, all reported since 1995, and discuss possible pathophysiologic mechanisms

These data suggest that the rate of serum ethanol clearance in children and adolescents presenting to the ED approaches that previously reported for adults. Clinical diminution of intoxication should not be more rapid for children and adolescents than it is for adults.

was overall survival (OS). Survival was estimated by KaplaneMeier method, and comparisons performed with log-rank test.Results: A total of 167 pts were included: median age was 55 years (18À81), 55.7% were females, 91% had an ECOG-PS !2, 75.4% had gastrointestinal primary tumors, and 70.1% had no previous systemic treatment. Median time from cancer diagnosis to MBO was 16 weeks (0-972.4), and median length of hospitalization after CTX was 2 weeks (0.1-13.6). Overall, a total of 159 deaths were observed, with a median OS of 4.4 weeks (95% confidence interval [CI], 3.4-5.5) after CXT administration, and 5.6 weeks (95% CI, 4.6-6.5) after MBO diagnosis. Treatment line, ECOG-PS and primary tumor did not impact OS. Intestinal function recovery was observed in 86 pts (51.5%) after CTX, out of whom 22 (25.5%) had a re-obstruction. Pts who recovered intestinal function had a longer OS when compared to those who did not (10 weeks vs. 2.1 weeks; p<0.001). Hospital discharge was possible in 51.5% of the pts, and it was significantly correlated with intestinal function recovery (p<0.001). Grade !3 toxicities occurred in 26.9% of the pts after CTX.Conclusions: MBO was associated with a poor prognosis in this mostly treatment naive population. The administration of CTX yielded a significant risk of toxicities, whereas it may provide a modest benefit of questionable clinical relevance in this scenario.Legal entity responsible for the study: The authors.

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