A cross sectional study was conducted from October 2016 to June, 2017 in two abattoirs to assess the major abnormalities causing organ and carcass condemnation in cattle, sheep and goat as well as their economic and public health importance. In this study, a total of 700 animals (240 cattle, 230 sheep and 230 goats) were systematically selected and thoroughly examined at AM and PM. The PM result showed 12.43% liver (15.4% in cattle, 13.9% in sheep and 7.83% in goat) were condemned mainly due to fasciolosis (4.86%), hydatid cyst (3.57%) and fibrosis (2.3%). Similarly 12% lung (14.2% in cattle, 12.6% in sheep and 9.13% in goat) were also rejected due to hydatid cyst (6.3%), hepatization (1.57%), adhesion (1.14%) and lung worm (1%). The main causes of condemnations in kidneys, heart and spleen were infarction, pericarditis and hydatid cyst. However, Cysticercus bovis infestation was the only problem caused total and partial carcass, tongue and heart condemnation in cattle. The estimated annual financial loss was about 20559.43 and 20232.85 USD at Haramaya and Aweday municipal abattoirs respectively. Concerning public health issue of hydatid cyst and C. bovis, questionnaire survey and interviews were carried-out on randomly selected 100 respondents to evaluate the awareness, practice and ways of transmission of the disease. Accordingly, majority of the respondents had the habit of eating raw meat (68%), consuming backyard slaughtered meat (53%), feeding dogs infected raw viscera (28%), had close contact with dog (57%) and drinking surface water (11%). Retrospective patient case-book (2015 and 2016) survey showed 0.167% (42/25096) human hydatidosis among patients admitted for X-ray and ultrasound examination and 1.89% (791/41812) Taenia saginata taeniosis based on stool examination. Generally, the present study showed many parasitic and nonspecific lesions causing huge financial loss and hazardous to public health; therefore, further study is recommend at the study areas.