No abstract

Quinazolines are organic compounds that are made up of two fused six-membered rings–benzene ring and pyrimidine ring. Referring to the various positions of N atoms in the cyclic ring, many other isomeric forms play a vital role in biological activities. There view article describes the main functional groups that are present in Quinazolines which are responsible for medicinal, antimicrobial, antiviral, antibacterial andanticancer actions. This review focuses on the properties of these functional groups responsible for various biological activities of Quinazolines. The heterocyclic ring structures are mainly responsible for the pharmacological effects of quinazolines. The presence of benzyl-, halo-, methoxy and amino derivatives has many anticancer, antimicrobial and antimalarial properties. The article aims to review the medicinal functionality of Quinazolines.

In 2019, human race again came across a highly transmittable and pathogenic viral infection viz. COVID-19 and along with its pandemic nature, caused severe acute respiratory syndrome (SARS), and owes its emergence from the local seafood market of Wuhan city, China. Corona virus is currently prevalent all over the world wherein it caused infection in more than 29,599,29 individuals worldwide with mortality rate nearby 6.84% in approximately 213 countries within a short span of time and the infection due to this virus is still on a higher verge. The data showed that the transmission rate of COVID-19 is higher than the previous viral infections, particularly because of changes in genetic recombination at S protein in the RBD region. Till now there is no approved treatment available against COVID-19 infection and has been observed for human to human transfer widely. The present review summarizes the etiology, transmission, epidemiology, possible approaches for the treatment of COVID-19 and Clinical trials.