Volatility, Uncertainty, Complexity, Ambiguity—in a VUCA world the moment of surprise is everywhere, making things extremely unpredictable and planning and strategizing far more challenging. The healthcare industry is witnessing seismic shifts as medicine becomes more personalised, health data becomes valuable, and data sharing becomes essential, demanding the healthcare sector to re-strategise. This research aims to understand the various innovations and change-management techniques based on technology that have been adopted by healthcare industries in today's VUCA world while exploring the innovations needed to drive the Indian healthcare sector in the years to come. Thus, it examines and highlight the implications of the rising emphasis being placed on innovations in the healthcare industry - helping the sector to re-strategise and face the changes in today’s VUCA world with greater clarity. This paper is also designed to call attention to and discuss contemporary perspectives taken by top healthcare organisations in India before and during the COVID-19 pandemic. This research is based on secondary data, including intensive analysis of research papers, media articles and grey literature reports, along with examining the recent innovations undertaken by the top healthcare companies and hospitals in India. The findings suggest that moving away from a supply-driven healthcare system toward a patient-centred system is necessary, and therefore organisations in India have to embrace innovation, agility, and adaptability in unison to brave the VUCA times.