Vocational evaluators must work with a very diverse set of people. The purpose of this article is to provide practical guidance to evaluate people from eight special populations (i.e., deaf and hard of hearing, blind and low vision, deafblind, homeless, older adults, speakers of other languages, substance use, and youth in transition). The eight populations are grouped according to two causalities: (a) body functions and (b) structural or environmental factors with the exception of substance users and youth in transition which are affected by both causalities. Regardless of cause, all of the groups discussed experience difficulties with day-to-day activities and community participation, including employment. Using a mini-case study approach the authors describe the population, offer a case that represents some of the critical elements, discuss a course of action, and present additional tips.