No abstract

Female pattern hair loss (FPHL) is a non-scarring alopecia resulting from the progressive conversion of the terminal (t) scalp hair follicles (HFs) into intermediate/miniaturized (i/m) HFs. Although data supporting nutrient deficiency in FPHL HFs are lacking, therapeutic strategies are often associated with nutritional supplementation. Here, we show by metabolic analysis that selected nutrients important for hair growth such as essential amino acids and vitamins are indeed decreased in affected iHFs compared to tHFs in FPHL scalp skin, confirming nutrient insufficiency. iHFs also displayed a more quiescent metabolic phenotype, as indicated by altered metabolite abundance in freshly collected HFs and release/consumption during organ culture of products/substrates of TCA cycle, aerobic glycolysis, and glutaminolysis. Yet, as assessed by exogenous nutrient supplementation ex vivo, nutrient uptake mechanisms are not impaired in affected FPHL iHFs. Moreover, blood vessel density is not diminished in iHFs versus tHFs, despite differences in tHFs from different FPHL scalp locations or versus healthy scalp or changes in the expression of angiogenesis-associated growth factors. Thus, our data reveal that affected iHFs in FPHL display a relative nutrient insufficiency and dormant metabolism, but are still capable of absorbing nutrients, supporting the potential of nutritional supplementation as an adjunct therapy for FPHL.

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The multicentre, parallel, randomised, controlled study assessed the impact of once-daily supplementation with 12 vitamins, 6 minerals and docosahexaenoic acid (DHA) on maternal biomarkers and child-specific parameters during pregnancy. The results indicated, among other things, improvement of the DHA and vitamin D status coupled with good tolerability and a high level of safety.

Functionalized Chloroenamines in Aminocyclopropane Synthesis. Part 13. Azaannulated Cyclopropanes -Rigid Building Blocks for Oligoamines. -With regard to naturally occurring oligoamines, especially in terms of their interactions with DNA, structural properties are important. Thus oligoamines possessing rigid building blocks are of interest. Starting from the piperazine (I) the reaction with nucleophiles leads to different diastereomers of the title cyclopropanes. NaBH4 gives (II); the same stereochemical result is observed for cyanide or MeLi as reagents. (I) with (V) gives mainly (VI) beside (VII) and (IV). Conformation and molecular flexibility of the compounds are studied and X-ray analyses performed for (VI) and (IV). -(SEIBEL, J.; VILSMAIER, E.; FROEHLICH, K.; MAAS, G.; WAGEMANN, R.; Tetrahedron 50 (1994) 3, 715-730;