We report the case of a 28-year-old woman with pain in the dorsal and lumbar spine of 2 years of evolution with a history of acne treatment with isotretinoin for 6 years. The findings by computed tomography showed skeletal vertebral hyperostosis. The use of vitamin A and its derivatives, such as isotretinoin, has been associated to the development of skeletal hyperostosis, and its severity seems to be related to the duration of treatment. Currently, the use of this drug is widespread in young patients with acne, even without medical prescription, unaware of the effects it can cause at the osteoarticular level.