The advantage of using plants in nanoparticles synthesis is that they are easily available, safe to handle and possess a broad variability of metabolites such as antioxidants, nucleotides and vitamins. The aim of this study was to investigate the effects of Green and Zimbro tea and also Green coconut water as a reducing and stabilizer agent in gold nanoparticle synthesis. The gold nanoparticles were characterized by UV-Vis absorption spectroscopy, X-ray diffraction (XRD), Dynamic light scattering (DLS) and Transmission electron microscopy (TEM) analysis. Their physical stability was determined using a UV-Vis spectrophotometer over several days during storage at room temperature. We observed that green chemical process to obtain gold nanoparticles did not require any external chemicals reagent for stabilization of nanoparticulate. Absorption measurements indicated that the plasmon resonance wavelength appears around 530 nm. X-ray diffractograms of gold nanoparticles evidenced the presence of Au-rich (fcc) phases. TEM analysis showed a homogeneous dispersion of nanoparticles and some agglomerates. Differences in size and shape of the nanoparticles were observed. Zeta potential of AuNPs synthetized in presence of Green tea was −33 mV indicating stability of the synthesized nanoparticles.

Gold nanoparticles (AuNPs) have several applications including in medicine. Considering cancer is one of the most common diseases for men and women, new treatments and more specific and effective drugs, which cause less side effects, have been actively pursued. Among them, gold-198 can be engineered as theranostic agent, working as contrast (exploiting gamma emission) and treatment agents (beta emission). Accordingly, a new procedure for the production of 14 nm diameter radioactive citrate protected gold-198 nanoparticles, which were then conjugated with bovine serum albumin utilizing 3-mercaptopropionic acid directly bound to AuNPs surface as anchoring groups, generating fully dispersible nanoparticles in aqueous media, is described. The effect of gamma and beta radiation on grafted BSA was evaluated by direct irradiation of the corresponding cold material and comparing with the damage caused on BSA grafted gold-198 nanoparticles prepared from a neutron activated gold foil. The investigation by fluorescence and Raman spectroscopy indicated that the damage to BSA chromophore groups is proportional to the dose (from 0.1 to 1 kGy) and that chromophores groups close to the particle surface are more prone to damage. Gold-198 nanoparticles conjugated with bovine serum albumin showed that process is much more localized next to nanoparticles surface since each gold core acts as a punctual radiation source. In short, AuNPs can enhance the damage caused by irradiation of cold nanoparticles and AuNPs@MPA-BSA is a suitable model to probe the effect of gamma and beta emitter on biomolecules. Furthermore, the strategy of diluting the gold-198 with cold gold atoms was shown to be suitable to control the activity of 198 AuNPs aiming medical applications since the damage to BSA was found to be proportional to the relative concentration of gold-198.

A nutrição infantil é imprescindível no tratamento das enfermidades, pois essas crianças apresentam diversas complicações, dependendo do estágio em que a doença se encontra principalmente a desnutrição, podendo acometer seriamente o paciente, tornando o nutricionista, um profissional obrigatório. O objetivo do estudo foi avaliar as terapias nutricionais em pacientes oncológicos infantis. Trata-se de uma revisão integrativa delineando as buscas nas bases de dados Scielo e BIREME, a busca foi realizada no mês de Outubro de 2018. Os critérios de inclusão foram: estar disponível na integra e estudos em português. O câncer nessa faixa etária estudada precisa de vários cuidados com o acompanhamento de uma equipe multidisciplinar, na temática abordada o

No abstract