Objective:The aim of this study was to explore nurses' knowledge regarding postoperative pain management Background: Effective management of pain in hospitalized patients is an important aspect of quality care delivery, optimal clinical outcomes and patient satisfaction. Nurses play an important role in pain management but it has been widely observed that nurses have limited knowledge about management of post-surgical pain.Methodology: A quantitative descriptive cross-sectional study was conducted in a private tertiary care hospital in Peshawar, Pakistan. Study included nurses working at bedside in post-operative units of the hospital. A self-developed questionnaire was used for data collection. Chi square test was used to analyse the data. Results:The level of knowledge was divided into poor, average, good and excellent categories. Percentage score of categories was, poor (0%); average (6.7%); good (71.7%); and excellent (21.7%). Conclusion:Current study showed that majority of nurses working in surgical units had good knowledge of post-operative pain management. The focus of current study was on the exploration of nurses' knowledge regarding post-operative pain management, further studies need to be conducted to explore barriers and factors affecting their knowledge regarding post-operative pain management.