Multigrid applied to fourth-order compact schemes for monodomain reaction-diffusion equations in two dimensions has been developed. The scheme accounts for the anisotropy of the medium, allows for any cellular activation model to be used, and incorporates an adaptive time step algorithm. Numerical simulations show up to a 40% reduction in computational time for complex cellular models as compared to second-order schemes for the same solution error. These results point to high-order schemes as valid alternatives for the efficient solution of the cardiac electrophysiology problem when complex cellular activation models are used.

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Background: RET fusions occur in 10-20% of pts with PTC. RET fusion testing enables identification of pts who may benefit from targeted treatments [tx]. This study described real-world RET fusion testing patterns for pts with PTC in France [FR], Germany [DE], Italy [IT], Spain [ES] and the UK.Methods: Real-world data were drawn from the Adelphi Thyroid Cancer Disease Specific Programme TM e a point-in-time survey conducted between July-December 2020 primarily with oncologists and endocrinologists in clinical practice. Physicians completed patient record forms for up to the next 4 consulting adult PTC pts. Study variables included demographics, diagnostic testing patterns, test results, timing of testing, test modalities, and samples used.