The purpose of this article is to provide a conceptual mapping of challenges in the open innovation model's implementation in service sector. For this aim, content analysis of scientific articles was performed using MAXQDA10, primarily in the industries of telecommunications, pharmaceutical, biopharmaceutical and automobile services. These articles were selected from a search using data base ISI Web of Knowledge and web content analysis. The open innovation's challenges for its implementation in service sector were grouped in three macro challenges cited as the most relevant by Chesbrough and Brunswicker [1]. These challenges are presented in three stages: organizational change management, external relationship management with innovation and commercialization sources and effectiveness of intellectual property protection.