No abstract

The association of the histological type with HPV-16 and the association of the grade of epithelial dysplasia with HPV DNA were highly significant. These associations support the adenoma-carcinoma hypothesis. In addition, the results suggest that HPV infection may be an important factor for the development of colorectal neoplasia.

The overexpression of p53 protein is uncommon in colorectal carcinoid tumors. However, the expression of p53 protein has a correlation with clinicopathologic-predicting criteria in colorectal carcinoid tumors and may be used as an associated prognostic parameter to assess patient survival.