No abstract

The finger print mass spectrum of saliva protein in patients with gastric cancer can be established using gastric cancer proteomics. A diagnostic model for distinguishing protein expression mass spectra of gastric cancer from non-gastric-cancer saliva can be established according to the different expression of proteins 1472.78 Da, 2936.49 Da, 6556.81 Da and 7081.17 Da. The method for early diagnosis of gastric cancer is of certain value for screening special biological markers.

Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. However, the biological function of nobiletin in breast cancer (BC) is largely unknown. To investigate the effect of nobiletin on growth of BC cells, the cell viability of BC was measured by MTT assay. In addition, gene and protein expressions were detected by qRT-PCR and western blot, respectively. The apoptosis and pyroptosis of BC cells were tested by flow cytometry. Finally, the correlation between miR-200b and JAZF1 was detected by dual luciferase report. The data indicated that nobiletin inhibited the proliferation of BC cells in a dose-dependent manner. Moreover, miR-200b mimics-induced pyroptosis of BC cells was further increased by nobiletin. Meanwhile, JAZF1 was found to be the target of miR-200b. Moreover, nobiletin induced apoptosis and pyroptosis of BC cells via miR-200b/JAZF1/NF-κB axis. In conclusion, nobiletin inhibited the tumorigenesis of BC via regulation of miR-200b/JAZF1 axis. Thus, nobiletin might serve as a new agent for the treatment of BC.

We consider the spin-1 Bose-Einstein condensates with the isotropic Rashba spin-orbit coupling in a two-dimensional torodial trap. Three types of striped phases are found in a non-rotational system, i.e., the stripe phase with the periodic density modulation along the azimuthal direction, the stripe phase with the periodic density modulation along both the azimuthal and the radial directions and the stripe phase with the periodic density modulation along the radial direction. By adding the rotation, the condensates occupy the mF = 0 component for small rotational frequency while occupy both the mF = 1 and mF = −1 components for large rotational frequency when both the relative interaction and the spin-orbit coupling are weak. For the stronger relative interaction and spin-orbit coupling, the vortices of the system are elongated along the radial direction and linked one after another. As the rotational frequency further increases, the density evolves from the elongated effect of the vortices into a laminar vortex ring.