We report for the first time that
the imidate radical can be efficiently
added to glycals to generate glycosyl radicals, based on which a general,
toxic-reagent-free synthesis of C-glycosides of 2-deoxy-2-amino
sugars has been developed. Complementary to previous strategies, the
reaction is 1,2-trans-stereoselective and could use
aryl alkenes as substrates. The late-stage functionalization and density
functional theory calculations are reported.
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