Traditional Live Wire algorithm distinguished the strength edge of objectives uneasily and executive speed of algorithm is slow. For these problems, an improved Live-Wire algorithm is proposed. First it implements anisotropic diffusion filtering to images and constructs a new expense function, then combined with region growing segmentation algorithm, it implements interactive segmentation to medical images. Improved algorithm avoids the shortcomings of the traditional Live-wire algorithm which is sensitive to noise and can not effectively distinguish the edge of the strength, also reduces the time and blindness of dynamic programming to find the optimal path and improves the accuracy and implementation efficiency of the image segmentation.