The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer.

Type 2 diabetes is known to cause endothelial activation resulting in the secretion of von Willebrand factor (VWF). We have shown that levels of VWF in a glycoprotein Ib-binding conformation are increased in specific clinical settings. The aim of the current study is to investigate whether active VWF levels increase during aging and the development of diabetes within the population of patients suffering from type 2 diabetes. Patients and controls were divided into two groups based on age: older and younger than 60 years of age. VWF antigen, VWF propeptide, VWF activation factor and total active VWF were measured. Patients older than 60 years of age had increased levels of total active VWF, VWF activation factor and VWF propeptide compared to younger patients and controls. All measured VWF parameters were associated with age in diabetic patients. Total active VWF and VWF propeptide correlated with the period of being diagnosed with diabetes. Regression analyses showed that especially the VWF activation factor was strongly associated with diabetes in patients older than 60 years of age. In conclusion, we found that the conformation of VWF could be involved in the disease process of diabetes and that the VWF in a glycoprotein Ib-binding conformation could play a role as risk marker during the development of diabetes in combination with an increase in age. Our study shows that the active quality of VWF was more important than the quantity.

In this paper, we have started from the point of view of bionics, doing surface bionic non-smooth design at the standard No.16 animal syringe needles. Then treating the concave as the bionic unit, we worked out the concave bionic drag reduction needles by use of the laser material remove processing means. In accordance with the national standard on the injection drag test of disposable needles, we did the puncture drag comparative test of the smooth needles and the bionic needles, getting the correspondence relationship between the drag reduction rate and the bionic unit parameters. We found that the maximum drag reduction rate up to 44.05%, and it appeared when the concave interval was 0.9mm and the concave diameter was 0.09mm. Then through discussing the drag reduction mechanism of the bionic needles, we knew that the bionic units reduced the actual contact area between the needle outer wall and the simulation skin, and it was the main reason of bionic needles puncture drag decreases.