In order to improve the effect of color matching in children’s room, this paper studies the color matching of children’s room combined with computer interactive experience technology. Moreover, this paper analyzes the basic knowledge of colorimetry, the principle of color measurement equipment, the basic concepts and mathematical models of color conversion, equipment color characteristic correction, and color gamut matching used in color management research and analyzes the color perception in the process of computer interaction experience. The color design method based on hue harmony is a color harmony design method extracted on the basis of the basic color system and Chevrel’s theory of color harmony. The experimental research shows that the indoor color matching system for children’s room based on computer interactive experience proposed in this paper has a good color matching effect.