The scientific research information system plays an essential role in improving management efficiency and promoting technological innovation in universities. With the increasing computational demand for human-centric research management, blockchain technology, with distributed storage, consensus sharing, and security traceability, has efficiently assisted the research information system in dealing with various issues such as big-data scale, information security, interconnection, rapid response, and private security. A novel scientific information system framework based on intelligent blockchain technology is proposed to promote university scientific research’s information level and management efficiency. Moreover, four smart data contracts, including data collection, verification, sharing, and supervision, are custom-designed under an efficient scientific research information system. Those intelligent contracts provide reliable data security and traceability algorithms to guarantee the practical application of the scientific research information system. The results show that the constructed system can relieve the centralized storage pressure of scientific research information and solve the cross-subject sharing obstacle of massive safety data among different systems. Thereby, the system increases the transparency of scientific evaluation and realizes the credible supervision of scientific research information, which provides a way to promote the innovative application of blockchain technology in scientific research management in colleges and universities.