No abstract

Dehydroxytrifluoromethylthiolation of alcohols with a PhPCFCO/S/F system is described. Difluorocarbene generated from PhPCFCO would readily combine with elemental sulfur to furnish S═CF. S═CF can be considered as a bifunctional intermediate, activating alcohol and providing scaffold for CFS formation, thus allowing for the convenient dehydroxytrifluoromethylthiolation of alcohols.

A new method has been developed for the Cu-catalyzed C-H trifluoromethylation of 3-arylprop-1-ynes for the selective construction of allenic Csp(2)-CF3 and propargyl Csp(3)-CF3 bonds. The selective formation of allenic Csp(2)-CF3 and propargyl Csp(3)-CF3 bonds can be controlled by modifying the reaction conditions.