In this paper, we study practical generalized synchronization of uncertain chaotic system with a given manifold Y = H(X). We construct a class of the bi-directionally coupled chaotic systems with impulsive control, and demonstrate theoretically that the bi-coupled systems could realize practical generalized synchronization on the basis of stability theory of impulsive differential equations. Numerical simulations with super-chaotic system are provided to further demonstrate the effectiveness and generality of our approach.