A novel water soluble, phosphate-based enrichable, retro-Michael addition-driven MS-cleavable and multi-targeting cross-linker was developed.

Use of N-methyl-N-phenylvinylsulfonamides to perform chemoselective modification of cysteine-containing peptides and proteins is reported. Probes linked to the drug were applicable to prepare antibody–drug conjugates (ADCs). The drug–antibody ratio for ADCs was controlled by rationally tuning the electron deficiency and linker hydrophilicity of the probes.

We investigate 2D topological gravity theories with matter fields turned on. We compute correlators of boundary creation operators with extra matter insertions. We provide a systematic procedure to determine a set of α-states on which the correlation functions of the different boundary operators factorize. Our results suggest that the boundary dual is an ensemble average of theories with different numbers of replicas of a seed matter contribution that is represented by excitations on top of the gravity sector. The construction of the α-states and the subsequent computations in the Hilbert space point of view are most conveniently done when the bulk couplings of the matter fields are expanded in a basis of vortices, which can be thought of as a 1-dimensional analogue of the SD-branes. We further demonstrate the existence of null states and the conditions imposed by reflection positivity. Moreover, in the CGS model with only disk and cylinder topologies we map the baby universe creation and annihilation operators to the coupling constants in the one time SYK model, which allows us to match the wormhole and half-wormhole contributions in the CGS model explicitly to those identified in the SYK model. This explicitly realizes Coleman's initial idea. Some details of the computations in a variety of concrete models are presented.

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