The professional and technical talents are the significant supporting factor for the leapforward development of economy and society, for the timely-completed political task of overcoming poverty and for the overall construction of moderately prosperous society in all aspects during the period of Five-Year Plan. Therefore, it is particularly urgent for Guizhou Province to study the scale of professional and technical talents due to the change of development strategy. In this study, based on the development of professional and technical personnel in Guizhou. The study constructed the forecast model, which is the combination of regression model and gray model. Besides, the study tried to circumvent the inherent limitations of single forecasting model with the purpose of improving the accuracy and scientific of forecasting, inspiring and enlightening the scientific development of Guizhou Province.