OBJECTIVE To investigate the clinical effi cacy and toxic eff ect of the 3-dimensional conformal radiation therapy (3DCRT) for nonsmall cell lung cancer (NSCLC). METHODS Fi y-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy (CRT). In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, se ing 4 to 6 coplanar or non-coplanar irradiation fi elds, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose (DT) of 66 Gy to 72 Gy. In the CRT group, the fi eld area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36~40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8~2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTSThe therapeutic effect (CR + PR) was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically signifi cant diff erence between the two groups, P < 0.01. There was a clinical symptom improvement a ained by 96.5% and 86.4% respectively in the two groups, and there was a statistically signifi cant diff erence between the groups, P < 0.01. The 6-month, 1 and 2-year overa1l survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P < 0.05. There was no obvious signifi cant diff erence in the 1 and 2-year overa1l survival rates between the two groups, P > 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically signifi cant diff erence between the groups, P < 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and be ering the quality of life.

No abstract

Review question / Objective: The aim of the review is to evaluate the effectiveness of music combined with action observation therapy in treating aphasias after stroke. Condition being studied: Aphasia is a common neurogenic language disorder caused by stroke in the left hemisphere. About 40% of all people who suffer from stroke develop aphasia. Patients with aphasia after stroke, which not only impair communication, but also decrease the INPLASY 1