Bone Repair In article number 2202044, Jiayong Dai, Jianxun Ding, Huanghao Yang, and co‐workers develop an osteoimmunity‐regulating biomimetically hierarchical scaffold to improve large‐scale bone‐defect regene ration through alleviating inflammation, enhancing neovascularization, stimulating osteogenesis, and inhibiting osteoclasts, facilitating the balance of the immune system and bone metabolism and augmenting bone repair.

Sequential Drug Delivery In article number 2200449, Di Li, Jianxun Ding, Tianmeng Sun, and co‐workers develop a tumormicroenvironments‐adapted gel composite for sequential drug release to reverse the epithelial–mesenchymal transition of tumor cells and regulate the tumor immune microenvironments, thereby inhibiting tumor growth and metastases. This process is like a painter using a paintbrush to turn a depressed and cold winter into a colorful and vibrant spring.

Tumor Therapy In article number 2110094, Jianxun Ding and co‐workers develop a versatile polymer, 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐poly(ethylene glycol)‐alendronate (DPA), for osteosarcoma blockade therapy. DPA not only initiates biomineralization in the peripheral tissue of tumors after insertion into the cytomembrane, but also alleviates bone destruction efficiently, both of which significantly inhibit the growth and lung metastasis of osteosarcoma.