Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C–F and C–N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.

Herein we report a nickel-catalyzed asymmetric reductive dicarbamoylation of alkenes, in which tethered carbamoyl chlorides and isocyanates serve as distinct electrophilic carbamoylating agents, providing new access to chiral oxindoles bearing an amide-substituted quaternary stereogenic center.

Review question / Objective: Parkinson's disease (PD), as a high incidence of nervous system diseases, is characterized by high disability rate and high mortality. However, the current medication does not bring satisfactory results. In recent years, more and more researchers have found t h a t s o m e n o n -p h a r m a c o l o g i c a l INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols