A novel and efficient synthesis of isatoic anhydride derivatives was developed via palladium-catalyzed multistep tandem carbonylation/N-dealkylation/carbonylation reaction with alkyl as the leaving group and tertiary anilines as nitrogen nucleophiles. This approach features good functional group compatibility and readily available starting materials. Furthermore, it provided a convenient approach for the synthesis of biologically and medicinally useful evodiamine.

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A palladium-catalyzed C3-selective C–H oxidative carbonylation for the synthesis of various esters from imidazo[1,2-a]pyridines and CO with high efficiency and high atom economy has been developed.

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as nontoxic combined cyano-group source and DMF as formylation reagent. Mechanistic studies indicate...