The developed spectroscopic method can be successfully applied in high-throughput screening of the antioxidant capability of Radix Scutellariae samples. It can also be a viable and advantageous alternative to laborious chemical procedures.
The stem bark of Magnolia officinalis is a traditional Chinese medicine for the treatment of abdominal distention and functional dyspepsia. The pharmacokinetics of three glycosides (magnoloside A, magnoloside B, and syringin) and two lignans (honokiol and magnolol) in both normal and functional dyspepsia rats were firstly investigated by ultra-performance liquid chromatography-triple quadrupole mass spectrometry method and the influences of the coexisting compounds on the pharmacokinetic parameters of honokiol and magnolol were also studied. It was found that all of the five target compounds were quickly absorbed and eliminated in both normal and functional dyspepsia rats, while, their residence time was significantly decreased in pathological states except magnoloside A. The coexisting compounds in the stem bark of M. officinalis significantly reduced absorption and increased elimination of honokiol in vivo. It's worth noticing that the volume of distribution of lignan was quite lower than that of a glycoside. Moreover, the metabolic profiling of magnoloside A, honokiol, and magnolol in vivo was analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method, from which three prototypes were identified and 35 metabolites were putatively characterized, and 18 unknown metabolites were reasonably characterized for the first time. The results indicated that sulfation and glucuronidation were the main metabolic pathways of honokiol and magnolol.
Feature matching between high-resolution satellite stereos plays an important role in satellite image orientation. However, images of changed regions, weak-textured regions and occluded regions may generate low-quality matches or even mismatches. Furthermore, matching throughout the entire satellite images often has extremely high time cost. To compute good matching results at low time cost, this paper proposes an image block selection method for high-resolution satellite stereos, which processes feature matching in several optimal blocks instead of the entire images. The core of the method is to formulate the block selection into the optimization of an energy function, and a greedy strategy is designed to compute an approximate solution. The experimental comparisons on various satellite stereos show that the proposed method could achieve similar matching accuracy and much lower time cost when compared with some state-of-the-art satellite image matching methods. Thus, the proposed method is a good compromise between matching accuracy and matching time, which has great potential in large-scale satellite applications.
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