IntroductionOver the past decade, several studies on the microvascular invasion (MVI) of hepatocellular carcinoma (HCC) have been published. However, they have not quantitatively analyzed the remarkable impact of MVI. Therefore, a more comprehensive understanding of the field is now needed. This study aims to analyze the evolution of HCC-MVI research and to systematically evaluate the scientific outputs using bibliometric citation analysis.MethodsA systematic search was conducted on the Web of Science Core Collection on 2 May 2022 to retrieve studies on HCC-MVI published between 2013 and 2022. Then, a bibliometric analysis of the publications was performed using CiteSpace, VOSviewer, and other visualization tools.ResultsA total of 1,208 articles on HCC MVI were identified. Of these, China (n = 518) was the most prolific country, and Fudan University (n = 90) was the most notable institution. Furthermore, we observed that Lau Wan Yee participated in most studies (n = 26), and Frontiers in Oncology (IF2020:6.24) published the highest number of documents (n = 49) on this subject, with 138 publications. The paper “Bray F, 2018, CA-CANCER J CLIN, V68, P394” has the highest number of co-cited references, with 119 citations. In addition, the top three keywords were “survival”, “recurrence”, and “microvascular invasion”. Moreover, the research hot spots and frontiers of HCC-MVI for the last 3 years included imaging characteristics and transarterial chemoembolization (TACE) therapy studies.ConclusionsThis study comprehensively summarized the most significant HCC-MVI documents from past literature and highlighted key contributions made to the advancement of this subject and the advancement of this field over the past decade. The trend of MVI research will gradually shift from risk factors and prognosis studies to imaging characteristics and TACE therapy studies.

Laparoscopic cholecystectomy is the standard treatment for cholelithiasis. A very rare condition named situs inversus should not be considered as a contraindication for laparoscopic cholecystectomy. Here, we reported a case of successful laparoscopic cholecystectomy in a patient with situs inversus totalis. We also described the technical advantages of this treatment and reviewed the literature.

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To study the regulatory effect of Sijunzi Decoction on intestinal flora and immune function in patients with colorectal cancer. 100 patients with colorectal cancer were divided into two groups. The control group was received routine chemotherapy, and the experimental group was taking Sijunzi Decoction based on routine chemotherapy. 16S RNA amplicon sequencing was used to quantitatively detect the intestinal flora, and the immune function of the patients was detected by Flow cytometry analysis. The digestive tract reaction was significantly reduced by Sijunzi Decoction, and the abundance of intestinal Lactobacillus and Bifidoacterium were increased, but the abundance of Enterobacteria and fusobacterium nucleatum were reduced. The proportion of CD4 + / CD8 + cells was increased as shown by Flow cytometry analysis. The species and abundance of intestinal flora were changed, and the immune function of patients with colorectal cancer were significantly improved by Sijunzi Decoction. Key words: Sijunzi Decoction; Colorectal Cancer; Intestinal Flora; Immune Function.

Purpose Over the past decade, several studies have been published regarding the microvascular invasion (MVI) of hepatocellular carcinoma (HCC).However, although these publications have had a remarkable impact on MVI, they have not been quantitatively analysed. Therefore, this study characterised the evolution in HCC-MVI research and systematically evaluated scientific outputs using bibliometric citation analysis. Methods We conducted a systematic search on the Web of Science Core Collection on 2 May 2022 to retrieve studies related to HCC-MVI published between 2013 and 2022. Then, Citespace (v.5.8R3), VOSviewer (v.1.6.18) and other visualisation tools were used to conduct a bibliometric analysis of the publications. Results We identified 1208 articles on MVI in HCC. Of these, while China (n = 518) was the most prolific country, Fudan University (n = 90) was the most notable institution. Furthermore, we observed that while Lau Wan Yee participated in most studies (n = 26), the Frontiers in Oncology (IF2020:6.24) published the highest number of documents (n = 49) on this subject, with 138 publications. The paper ‘Bray F, 2018, CA-CANCER J CLIN, V68, P394’ also presented the highest co-cited references, with 119 citations. Additionally, the top three keywords were ‘survival’, ‘recurrence’ and ‘microvascular invasion’. Moreover, the research hotspots and frontiers in HCC-MVI for the last three years included ‘image’ and ‘tace’. Conclusion This study comprehensively summarised the most significant HCC-MVI documents from past literature (2013–2022) and highlighted key contributions made to the advancement of this subject and the advancement of this field over the past decade. We propose that this information would provide clinicians and researchers insight into future directions relative to the advancement of HCC-MVI.