The rapid advances in Information and Communication Technology (ICT), management, and network technologies have had key role in emerging heterogeneous large-scale distributed systems. The term of E-nursing has been used to refer to the incorporation of ICT into nursing. An Autonomous system has as its vision the creation of self managing systems to address today's concerns of complexity and total cost of ownership while meeting tomorrow's needs for pervasive and ubiquitous computation and communication. Purpose of this paper is to present an autonomous virtual organization for e-nursing describing their characteristics, effects on quality factors, their building blocks architecture, and challenges.