Probiotics are microorganisms that provide a positive effect on the host where Lactobacillus and Bifidobacteruim are the most frequent species in this group; on the other hand prebiotics are substances that provide a selective stimulation of growth to species beneficial to humans such as those mentioned above, where inulin or oligofructose are the most representative substances in this category. The intestinal flora represents a great variety of microorganisms such as Bacteroides, Faecalibacterium, Bifidobacterium among others, maintaining a homeostasis in its environment, however in patients with chronic renal failure (CKD) show an increase in the intestinal level of aerobic bacteria such as Firmicutes, Actinobacteria and Proteobacteria resulting in an increase of metabolites such as phenols, indoles and amines that contribute to uremic toxicity. It is known that the use of probiotics and prebiotics have many applications in the medical field, from cardiovascular diseases, diarrhea, allergies, Helicobacter pylori erradication, nephropathies to use in cancer patients. The increase in the number of patients with chronic renal failure) and the mechanisms of action by these microorganisms could represent an alternative in these patients. However, the scientific evidence in this area is limited, which represents an area of opportunity. Through the analysis, we intend to present scientific evidence in the use of probiotics (lactobacillus rhamnosus NH001, Bifidobacteriumlactis Bi07) and prebiotics (blue agave inulin) as an alternative treatment in patients with renal failure for the significant decrease in toxin levels.