Sustainability assessment is widely used to monitor public policy toward sustainable development (SD). However, such tools have been less developed at the local level. This research examined sustainability indicators (SIs) applied at the neighborhood scale. The indicators were developed by examination of previously developed sustainability rating systems and issues specific to the City of Birmingham, Alabama, USA. The indicators of Neighborhood Sustainability Assessment (NSA) systems addressed the three major dimensions of sustainability: economic, environmental, and social. The rating system was applied to all neighborhoods, and geographical patterns were analyzed. The ability to analyze the sustainability of all neighborhoods within the city provides information on which areas are performing well and which areas need more attention to become more sustainable.