Right on target: An in vivo tumor‐targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper‐free click reaction.
Gold nanoprobe: Heparin–DOPA‐coated gold nanoparticles (HEPA–AuNPs) showed low toxicity, prolonged stability, and an enhanced X‐ray absorption coefficient in vitro. In vivo microCT images showed that HEPA–AuNPs produced enhanced liver‐specific CT images compared with iodine‐based contrast agents, thus highlighting its potential as a novel, liver‐specific CT imaging agent (see figure).
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