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Lower folate, lower vitamin B(12) and raised homocysteine levels may be risk factors for late-life depression.

Having fewer teeth may be a marker of risk for dementia. This might be explained by specific nutritional deficits, or by other side effects of periodontal disease. Further prospective research is indicated.

Methylphenidate and sertraline had similar effects on depressive symptoms. However, methylphenidate seemed to be more beneficial in improving cognitive function and maintaining daytime alertness. Methylphenidate also offered a better tolerability than sertraline.