Based on statistics of Inner Mongolia of China, this paper studied the regional differences and influence factors of inbound tourism economy by analyzing the range, standard deviation, coefficient of variation and RHL. The results showed that the regional differences of inbound tourism economy were large. From the viewpoint of differences in regional development, the highest level was eastern Inner Mongolia and the lowest one was western. While from the viewpoint of urban differences, Hulunbeier and Xilingol’s development was highest, Wuhai and Hinggan’s development was lowest. The absolute discrepancy increased and the relative discrepancy reduced gradually. The main influence factors of regional difference included scenic area number, traffic conditions, geographical location and tourist market surrounding. However, the change of difference in inbound tourism economy was rarely influenced by the development level of regional economy, but only closely related to the local development of agricultural economy.