α,α-Difluoromethyl carbinols are important structural motifs in many therapeutic agents and functional materials. Herein, we developed a sustainable and efficient method for the synthesis of a series of α,α-difluoromethyl carbinols...

This paper reports a practical and versatile oxidative cyclization of 2-arylethynylanilines towards 2-hydroxy-2-substituted indol-3-ones via a copper-catalyzed radical approach in the presence of O2. The transformation of 2-hydroxy-2-arylindol-3-ones to 3-hydroxy-3-arylindol-2-ones...

Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Herein we report the synthesis of 3,3-difluoro-4-(silyloxy)but-1-en-1-yl)benzamides from the unprecedented rhodium(III)-catalyzed alkenylation of various benzamides with difluorohomoallylic silyl ethers. The...