Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy including chemotherapy, radiotherapy, photodynamic therapy, etc. In recent years, the construction of hypoxia‐relieving functional nanoplatforms through nanotechnology has become a new strategy to reverse the current situation of tumor microenvironment hypoxia and improve the effectiveness of tumor treatment. Here, the main strategies and recent progress in constructing nanoplatforms are focused on to directly carry oxygen, generate oxygen in situ, inhibit mitochondrial respiration, and enhance blood perfusion to alleviate tumor hypoxia. The advantages and disadvantages of these nanoplatforms are compared. Meanwhile, nanoplatforms based on organic and inorganic substances are also summarized and classified. Through the comprehensive overview, it is hoped that the summary of these nanoplatforms for alleviating hypoxia could provide new enlightenment and prospects for the construction of nanomaterials in this field.

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Purpose The spherical hybrid sliding bearings (SHSBs) can be used in ultra-precision and heavy-duty machine tools. However, there is little related research for these bearings. The purpose of this study is to investigate the static characteristics and effect factors affecting SHSBs by fluid lubrication. Design/methodology/approach Based on the theories of fluid lubrication, the Reynolds equation of general Newtonian fluid is derived to obtain the steady-state lubrication equation. The system is solved by the finite difference method and the relaxation iterative method on the staggered grid to obtain the thickness and the pressure distribution of the oil film. The radial and axial load capacities of SHSBs are determined by the pressure field integration over the spherical surface. Findings The results show that the parameters such as oil supply pressure, bearing clearance, eccentricity ratio, rotating speed and orifices’ number affecting the static characteristics of bearings are significant and the cross-coupling effect exists. Originality/value The lubrication model of SHSB is established to analyze the pressure distribution with a variety of oil film thickness. The laws of oil supply pressure, bearing clearance, eccentricity ratio, rotating speed and orifices’ number on the load capacities are researched.