In order to improve the evaluation effect of the economic and social development pioneer area, this paper constructs the evaluation index system of the economic and social development pioneer area based on the spatial network structure analysis method and obtains an intelligent analysis system. Moreover, from the perspective of economic development information flow, this paper uses information flow direction analysis method and advantage flow analysis method to discuss the structural characteristics of urban economic development network in the economic belt, providing new methods and perspectives for the study of urban economic development flow. In addition, this paper attempts to propose a universal method for quantitative research on the “flow space” structure of urban economic development as the forward-looking content of urban economic development. According to the simulation test results, it can be seen that the evaluation index system of the economic and social development pilot area based on the analysis of the spatial network structure proposed in this paper has a good effect.