These findings indicate that HSF4 represses vimentin gene expression via the HSE-like element. The loss of HSF4 function results in an increase in vimentin expression in Hsf4(tm1Xyk)-knockout mice and affects lens differentiation, particularly impairing the denucleation of lens fiber cells. These events appear to implicate a molecular mechanism in abnormal lens development and cataract formation in Hsf4(tm1Xyk)-knockout mice. The HSF4-vimentin axis appears to be a new target for developing anti-cataract drugs, especially for those cataracts resulting from aberrations in HSF4 expression.

For the multinational chemical company, a reasonable distribution center location decision needs to consider the chemical product characteristics, logistics costs, logistics response speed etc. Establishing a logistics distribution center in North China is significant for the company. Based on the analysis of logistics costs, this paper chose gravity method to obtain the optimal distribution center location, and did a comprehensive analysis of the actual situation and then come to a reasonable distribution center location.