During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B.1.617.2) variant was first reported in India in October 2020 and was classified as a “variant of concern (VOC)” by the WHO on 11 May, 2021. Compared to the wild-type strain, several studies have shown that the Delta variant is more transmissible and has higher viral loads in infected samples. COVID-19 patients infected with the Delta variant have a higher risk of hospitalization, intensive care unit (ICU) admission, and mortality. The Delta variant is becoming the dominant strain in many countries around the world. This review summarizes and analyses the biological characteristics of key amino acid mutations, the epidemic characteristics, and the immune escape of the Delta variant. We hope to provide scientific reference for the monitoring and prevention measures of the SARS-CoV-2 Delta variant and the development strategy of a second-generation vaccine.

The [Ni(IMes)2]-catalyzed transformation of fluoroarenes into arylboronic acid pinacol esters via C-F bond activation and transmetalation with bis(pinacolato)diboron (B2pin2) is reported. Various partially fluorinated arenes with different degrees of fluorination were converted into their corresponding boronate esters.

Abstract-We propose a novel approach to enable the coexistence between Multi-Input-Multi-Output (MIMO) radar and downlink multi-user Multi-Input-Single-Output (MU-MISO) communication system. By exploiting the constructive multi-user interference (MUI), the proposed approach trades-off useful MUI power for reducing the transmit power, to obtain a power efficient transmission. This paper focuses on two optimization problems: a) Transmit power minimization at the base station (BS) while guaranteeing the receive signal-to-interference-plus-noise ratio (SINR) level of downlink users and the interference-to-noise ratio (INR) level to radar; b) Minimization of the interference from BS to radar for a given requirement of downlink SINR and transmit power budget. To reduce the computational overhead of the proposed scheme in practice, an algorithm based on gradient projection is designed to solve the power minimization problem. In addition, we investigate the trade-off between the performance of radar and communication, and analytically derive the key metrics for MIMO radar in the presence of the interference from the BS. Finally, a robust power minimization problem is formulated to ensure the effectiveness of the proposed method in the case of imperfect Channel State Information (CSI). Numerical results show that the proposed method achieves a significant power saving compared to conventional approaches, while obtaining a favorable performance-complexity trade-off.

During the COVID-19 pandemic, genetic variants of SARS-CoV-2 have been emerging and spreading around the world. Several SARS-CoV-2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and April 2021. Studies have shown that many SARS-CoV-2 variants are more infectious than early wild strain and produce immune escape. These SARS-CoV-2 variants have brought new challenges to the prevention and control of COVID-19. This review summarizes and analyzes the biological characteristics of different amino acid mutations and the epidemic characteristics and immune escape of different SARS-CoV-2 variants. We hope to provide scientific reference for the monitoring, prevention, and control measures of new SARS-CoV-2 variants and the development strategy of the second-generation vaccine.