Background: In order to get the baseline data of Chinese hospital overall medical reformation and investigate the drug indicators, prescribing trends and economic data, we investigated the data before administrative interventions with the historical control method. Method: According to the WHO/INRUD criteria and cross-sectional studies, the retrospective method and equal sample interval of systematic sampling were used. We sampled from daily ordinary prescriptions, computed the drug indicators, prescribing trends and economic data and compared the mean of twelve days. Result: We sampled 1171 from 38246 adult ordinary prescriptions, the sampling percent was 3.06%, percentage of drugs prescribed by generic name 100.00%, In 2012-2014, the percentage of antibiotic cost in the daily drug cost decreased from17.44% to 8.01%, percentage of prescriptions with an antibiotic prescribed decreased from 12.64% to 9.64%, percentage of encounters with an injection prescribed decreased from 15.21% to 12.77%, the percentage of antibiotic cost in the daily drug cost decreased from 17.44% to 8.01%.Conclusion: By comparing the related data, most indicators were in decreasing trend and becoming more rational, administrative interventions had greatly most prescribing indicators, our hospital overall medical reformation was steadily advanced.