Pregnancy luteoma is a rare condition of the ovary preceded by pregnancy. It is a distinctive, non-neoplastic lesion of the ovary. It is characterized by proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium. 1 It is associated with varied symptoms, for instance, hirsutism, acne, deepening of voice, and virilization. 2 The first case was reported by Sternberg and Barclay in 1966. To date, very few cases have been documented in the literature. 3 The Chinese and English reports are generally individual cases. We collected 18 cases with literature review to analyze their pathology and clinical characteristics so as to improve the pathology and clinician understanding of the disease.

Objective Human papillomavirus (HPV) infection is the risk factor for cervical cancer. Consequently, HPV DNA testing is an essential method for cervical cancer screening. Yet, data on the prevalence and genotype distribution of HPV and cervical cytological among women in northern Jiangsu Province of China are very limited. Materials and Methods A total of 36,500 women were enrolled at the Department of Pathology of Jinhu County People’s Hospital between January 1, 2016 and December 31, 2019. HPV genotypes was performed using YanengBio ® Human Papillomavirus Genotyping Kit. Thin liquid cytology tests (TCT) were conducted, based on cytology conditions set by Bethesda in 2001. Results The overall prevalence of HPV infection was 28.95%; it was age-dependent; the number of infections was highest in the 40–49 age group. Six thousand three hundred eighty-two women (16.87%) were found to have a pure high-risk HPV infection, while 918 women (2.43%) were found to have a pure low-risk HPV infection. The 6 most predominant genotypes were HPV 52, 58, 16, 53, 56, and 33. Moreover, 8923 women (45.09%) were affected by ASCUS, 4531 (22.90%) by LSIL, 3726 (18.83%) by ASC-H, and 2610 (13.19%) by HSIL. Conclusion This study revealed a high burden of HPV infection among women in northern Jiangsu Province of China and identified the distribution of the prevalent top 6 HPV genotypes in this area, which can be used as a useful reference for future work.

Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had long-term nasal catarrh with a runny nose and was admitted to the hospital. Computed tomography (CT) examination revealed polypoid mass in the nasopharynx. Pathological examination revealed typical papillary growth pattern of glandular epithelial cells. Immunohistochemical (IHC) staining showed the tumor cells to be diffusely positive for cytokeratin 7 (CK7), vimentin, and thyroid transcription factor 1 (TTF-1). The Ki-67 proliferation index was approximately 1%. In situ hybridization for latent Ebstein-virus (EBV) injection was negative. The patient did not exhibit recurrence or metastasis of the tumor.

Objective: To investigate the expression and clinical significance of MTA2 and CPNE1 proteins in cervical squamous cell carcinoma. Materials and Methods: In this experiment, High-risk HPV typing was performed on all cervical cancer tissues.RT-PCR and immunochemical EliVision method were used to examine the expressions of MTA2 and CPNE1 in the cervix and their relationship with clinicopathological features. Results: We found that it is mainly distributed in these types, namely 16(23.8%), 18(20.9%), 53(17.1%), 52(15.5%), 82(11.7%), 56(10.8%). The expressions of MTA2 and CPNE1 in cervical squamous cell carcinoma tissues were significantly higher than those in normal tissues, and the difference was statistically significant(P<0.01). The expressions of MTA2 and CPNE1 were correlated with FIGO stage, degree of differentiation, and lymph node metastasis of cervical cancer (P<0.05), but not with patient age (P>0.05）the rank correlation coefficient of MTA2 and CPNE1 protein expression in cervical squamous cell carcinoma was 0.668 (P<0.01), and the two expressions were positively correlated.Conclusions: MTA2 and CPNE1 are closely related to the occurrence and development of cervical squamous cell carcinoma, and may play a synergistic role in the evolution of cervical squamous cell carcinoma.

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