Road traffic accidents caused by fatigue driving are common causes of human casualties. In this paper, we present a driver fatigue detection algorithm using two-stream network models with multi-facial features. The algorithm consists of four parts: (1) Positioning mouth and eye with multi-task cascaded convolutional neural networks (MTCNNs). (2) Extracting the static features from a partial facial image. (3) Extracting the dynamic features from a partial facial optical flow. (4) Combining both static and dynamic features using a two-stream neural network to make the classification. The main contribution of this paper is the combination of a two-stream network and multi-facial features for driver fatigue detection. Two-stream networks can combine static and dynamic image information, while partial facial images as network inputs can focus on fatigue-related information, which brings better performance. Moreover, we applied gamma correction to enhance image contrast, which can help our method achieve better results, noted by an increased accuracy of 2% in night environments. Finally, an accuracy of 97.06% was achieved on the National Tsing Hua University Driver Drowsiness Detection (NTHU-DDD) dataset.