No abstract

Background: HSP27 phosphorylation plays pivotal roles on F-actin polymerization and actin cytoskeleton organization. Results: The loss of hTid-1 S expression was observed in lesional human psoriatic skin. Conclusion:The binding of hTid-1 S with MK5 inhibits HSP27 phosphorylation and attenuates F-actin polymerization. Significance: The lack of hTid-1 S expression correlates with the aberrant actin cytoskeleton organization in psoriatic human skin.

We report a Notch signal-induced pathway that leads to transcriptional activation of HIF1-α gene. HeLa/rtTAA/ TRE-