A novel and efficient approach to the synthesis of 2‐substituted benzimidazoles has been developed via CuI/DMEDA‐catalyzed coupling reaction and post‐cyclization with glacial acetic acid from readily available 2‐iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.

Transition-Metal-Free Synthesis of Quinoxalines from o-Phenylenediamines andArylacetaldehydes under Basic Conditions. -The novel approach furnishes the quinoxalines in moderate to good yields by the direct oxidative condensation of o-phenylenediamines with arylacetaldehydes. The one-pot procedure proceeds smoothly in air without adding any transition-metal catalyst, although with low to moderate regioselectivities. An inorganic base is the only reagent required. Various substituents are tolerated. However, heterocyclic and aliphatic diamines, as well as alkyl aldehydes do not afford the desired products. -(SONG, J.; LI, X.; CHEN, Y.; ZHAO, M.; DOU, Y.; CHEN*, B.; Synlett 2012, 16, 2416-2420, http://dx.

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A novel method for the synthesis of quinoxalines via transition-metal-free cyclization of o-phenylenediamine and arylacetaldehyde in a one-pot procedure has been developed. In this process, an inorganic base (K 2 CO 3 ) is the only reagent required, and it proceeds smoothly in the absence of adding transition metal catalysts. The reaction appears to be very general and suitable for the construction of a variety of quinoxalines.

Facile One-Pot Synthesis of N-Alkylated Benzimidazole and Benzotriazole from Carbonyl Compounds. -An efficient and convenient protocol for the synthesis of N-alkylated benzimidazoles and benzotriazoles using carbonyl compounds as alkylating agents is developed. -(MENG, X.; LI, X.; CHEN, W.; ZHANG, Y.; WANG, W.; CHEN, J.; SONG, J.; FENG, H.; CHEN*, B.; J. Heterocycl. Chem. 51 (2014) 2, 349-356, http://dx.