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The design of overlay pavement in Korea, using the American empirical method, does not consider the unique Korean climate, pavement material, and traffic conditions. Therefore, in this study, a mechanistic–empirical design catalog for bonded concrete overlays (BCO) that are appropriate for Korean pavement conditions was developed. First, the thickness of the new pavement slab was determined through the Korean pavement design method, which uses a mechanistic–empirical design program according to the traffic volume of the region with the worst climatic conditions in Korea. Then, finite element analysis models of new jointed concrete and BCO pavements were developed to determine the BCO thickness by adjusting it until the stress–strength ratio of an existing slab of BCO pavement was equal to that of a new concrete pavement slab. By repeating this procedure, a design catalog was developed for the sustainable management of concrete pavement according to the traffic volume, elastic modulus, and thickness of the existing slab after milling. The appropriateness of the BCO thickness predicted by the design catalog was verified by comparing it with that predicted by other design methods.

Common stereoscopic three‐dimensional (3D) display has a convergence and accommodation conflict that violates the natural human cognitive process of viewing. This weakness exposes the challenge in supporting fun factors while eliminating safety problems in the 3D viewing experience. Thus, human factors have become a major research topic. In this letter, we propose a 3D stereoscopic visualization platform that can expand the sense of a 3D space by fusing organically mixed stereoscopic displays to provide a continuous feeling of 3D depth. In addition, we present pilot test results to show the possibility of the technical implementation of the proposed platform and note ongoing research issues to be addressed.

This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured via enzyme-linked immunosorbent assay, as a biomarker of KMRC011 bioreactivity. Decreased tolerability, increased neutrophil count, hepatic enzyme concentration, C-reactive protein concentration, and interleukin-6 concentration after the administration was observed and ceased within 24 h without additional treatment. Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. These results suggest that KMRC011 may be used as an adjuvant for radiotherapy without severe adverse effects, especially during short-term radiotherapy, such as hypofractionated radiotherapy or stereotactic radiotherapy.

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