Scientific thinking is considered to be an important factor influenced the scientific learning achievements and the goal of providing the thinking skills. Therefore, the purpose of this research was attempted to develop the scientific thinking for 4th Grade students using Predict-Observe-Present-Explain (POPE) activity management to achieve the 70% criteria. The target group was 6 students of 4th Grade students at a primary school, Ban Don Santi School, Maha Sarakham Province, Northeastern Thailand. The participants chosen by the purposive sampling was studying in the second semester of the academic year 2021. The research instruments were 1) the twelve lesson plans for Predict-Observe-Present-Explain (POPE) activity, 2) the multiple choices test for the scientific thinking and 3) the observation form of scientific thinking. Data were analyzed and expressed as mean, percentage and standard deviation. The findings demonstrate that the percentage score of students’ scientific thinking was 65% for the first learning cycle and 79.45% for the second learning cycle that using the developed POPE activityThe obtained results from this research indicate that predict-observe-present-explain (POPE) activity management is a learning strategy that can be used for developing the scientific thinking to achieve the 70% of the scientific thinking criteria and applied for developing other scientific performances.